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methylprednisolone will reduce the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
hydrocortisone will decrease the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Keep an eye on Closely (one)oxcarbazepine will decrease the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
activity to be a neuronal voltage gated calcium channel blocker in rats.34 In addition it binds to a novel benzodiazepine receptor,
Paradoxical reactions may possibly arise which includes hallucinations, aggressive conduct, and psychoses; dinscontinue use if reactions arise
enasidenib will raise the amount or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Enasidenib (a weak CYP2C19 inhibitor) may perhaps boost systemic exposure of delicate CYP2C19 substrates. Watch and adjust dose of substrate as clinically indicated.
Reserve concomitant prescribing of such drugs in patients for whom other cure alternatives are inadequate. Limit dosages and durations towards the minimum amount required. Monitor closely for indications of respiratory melancholy and sedation.
If you are Expecting, your title could be detailed with a pregnancy registry to trace the effects of diazepam on the child.
In case you are prescribed diazepam for in excess of 4 months, your dose may be diminished slowly to avoid withdrawal indications.
fentanyl iontophoretic transdermal method and diazepam equally get more info raise sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom choice cure selections are inadequate
fludrocortisone will minimize the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
apalutamide will minimize the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications that are CYP3A4 substrates may result in reduce publicity to those remedies.
griseofulvin will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
apalutamide will decrease the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications that are CYP3A4 substrates can result in reduced publicity to these prescription drugs.